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Saturday, April 18, 2020 | History

4 edition of Modulation of macrophage procoagulant activity by platelet activating factor found in the catalog.

Modulation of macrophage procoagulant activity by platelet activating factor

Daryl Stanton Kucey

Modulation of macrophage procoagulant activity by platelet activating factor

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  • 16 Currently reading

Published by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .
Written in English


Edition Notes

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative.
ID Numbers
Open LibraryOL14711805M
ISBN 100315742151
OCLC/WorldCa30071846

  Activating-type FcγRs but not FcγRIIB mediates IgG-bound platelet-induced regulatory response in a mouse monocyte setting in vitro. (A) Mouse bone marrow (BM) cells were incubated with LPS in the presence of human platelets and an anti-human/mouse CD61 mAb (6E4), and then the production of IL and IL-6 was assessed after 24 by: The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood ; 23 Kasper BB. et al. Platelet factor 4 (CXC chemokine ligand 4) differentially regulates respiratory burst, survival, and cytokine expression of human monocytes by using distinct signalling pathways. J Cited by: Platelet activity is primarily associated with the initiation of coagulation cascades. Platelet adhesion to the extracellular matrix is the rst step in primary hemostasis. Under the conditions of high shear, von Willebrand factor (vWF) forms a bridge between exposed collagen and the platelet glycoprotein (GP) Ib-IX-V receptor complex on the. Platelet activating factor acetylhydrolase (PAF-AH) has been recognized for its ability to cleave and thus inactivate PAF (McIntyre et al ).The enzyme was shown to hydrolyze fragmented saturated OxPLs (Stremler et al ), as well as long-chain OxPLs, including esterified F2-isoprostanes, PC-hydroperoxides and PEIPC (Kriska et al Cited by: 5.


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Modulation of macrophage procoagulant activity by platelet activating factor by Daryl Stanton Kucey Download PDF EPUB FB2

Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and is also involved in changes to vascular permeability, the oxidative burst, chemotaxis of leukocytes, as well as CAS Number: Platelet-activating factor modulates endotoxin-induced macrophage procoagulant activity by a protein kinase C-dependent mechanism.

D S Kucey, P Y Cheung, and O D Rotstein Department of Surgery, Toronto General Hospital, Ontario, by: Factor IXa and platelet-bound factor Va support these activities. In addition, plate-lets can support the initiation phase of coagulation by providing binding sites for prothrombin and factor XI. They thereby take over the initia-ting role of tissue factor and factor VIIa in.

JOURNAL OF SURGICAL RESEA () Platelet-Activating Factor Primes Endotoxin-Stimulated Macrophage Procoagulant Activity DARYL S. KUCEY, M.D., ELIZABETH I.

KUBICKI,AND ORI D. ROTSTEIN, M.D. Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5G 2C4 Presented at the Annual Cited by: Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion Author links open overlay panel Diane E.

Lorant a b Guy A. Zimmerman a c Thomas M. McIntyre a c d Stephen Modulation of macrophage procoagulant activity by platelet activating factor book.

Prescott a c d eCited by: Ethanol modulation of the effects of platelet-activating factor on human platelets and a macrophage cell line. Baker RC(1).

Author information: (1)Department of Pharmacology, University of Colorado Health Sciences Center, Denver Author: Baker Rc. Cell populations were analyzed by flow cytometry after labeling with macrophage-specific antibodies.

Twenty-seven percent of the cells obtained after enzymic digestion and Ficoll-Paque density gradient centrifugation had macrophage surface markers. The decidual cell population secreted PAF-acetylhydrolase (PAF-AH) by: Activities of enzymes which metabolize lysoplatelet-activating factor (lysoPAF) and platelet-activating factor (PAF) were studied in rabbit alveolar macrophage lysates.

Substantial acetyltransferase activity was noted in the presence of μM acetyl-coenzyme A (CoA), and this activity was increased in Astimulated cell by: 4. Homologous endogenous transfer factor primed resident macrophages to subsequent exposure to platelet activating factor, while heterologous factor desensitized them.

Thus, desensitization effect caused by transfer factor observed after lipopolysaccharide injection in vivo was due to mutual effects of peritoneal and splenic macrophage by: 1. In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned.

At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of by: Introduction.

The single Platelet-activating Factor receptor (PAFR) is a G-protein coupled receptor present in the plasma and nuclear membranes of the majority of cells of the vascular and innate immune system that activates a variety of pathways involved in inflammation, oncogenic transformation, tumor growth, angiogenesis and metastasis.

Platelet activation takes place after attachment and adhesion events or after other stimuli that triggeres activation mechanisms such as thromboxane A2, ADP, thrombin or PAF (platelet activating factor, released from endothelial cells, PMN or monocytes).

In a first step of activation, platelets undergo shape change, cytoskeleton rearrangement. Antibodies for proteins involved in platelet activating factor receptor activity pathways, according to their Panther/Gene Ontology Classification. Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.

Macrophages are able to phagocytose monosodium urate monohydrate (MSU) crystals without releasing inflammatory factors. This study analysed macrophage Cited by: 4. Macrophage derived platelet activating factor (PAF) and related molecules could, according to one hypothesis, play a role in suppressing the inflammatory response.

MPIF - Macrophage Procoagulant Inducing Factor. Looking for abbreviations of MPIF. It is Macrophage Procoagulant Inducing Factor.

Macrophage Procoagulant Inducing Factor listed as MPIF. Macrophage Procoagulant Inducing Factor - How is Macrophage Procoagulant Inducing Factor abbreviated. Macrophage-Activating Factor for Glucose Consumption. Platelet-Activating Factor Proceedings ofthe second National Heart and LungInstitute Workshop, held on 1 July at the National Heart and LungInstitute, London Platelet-activatingfactor: apotentmediatorofinflammation ndP.J.

Barnes DepartmentofThoracicMedicine,NationalHeart&LungInstitute, DovehouseStreet, Cited by: 5. It is Monocyte Procoagulant Inducing Factor. Monocyte Procoagulant Inducing Factor listed as MPIF. Monocyte Procoagulant Inducing Factor - How is Monocyte Procoagulant Inducing Factor abbreviated.

MPIF: Macrophage Procoagulant Inducing Factor: MPIF: Monocyte Procoagulant Inducing Factor Monocyte Chemotactic and Activating Factor. Platelet activating factor (PAF) is a lipid mediator that appears to be involved in the pathophysiology of several allergic reactions such as anaphylaxis and potentially urticaria and allergic rhinitis.

The role of rupatadine, a drug with dual antihistamine and anti-PAF effect, in mast cell (MC) degranulation is not : Joaquim Mullol, Rosa Muñoz-Cano, I Torres-Atencio, E Ainsua, M Martin, J Sanchez-Lopez, Joan Bartra.

Cancer procoagulant, cysteine proteinase (CP; EC ) activates factor X and functions in the absence of factor VII. CP may also change the platelet function. It induces an increase of. Platelet factor 4 (PF4) is an abundant platelet α-granule chemokine released following platelet activation.

PF4 interacts with thrombomodulin and the γ-carboxyglutamic acid (Gla) domain of protein C, thereby enhancing activated protein C (APC) generation by the thrombin-thrombomodulin complex. Administration of a single high dose ( mg/kg) of 5-FU resulted in a decrease in the platelet count of peripheral blood at 5 days and subsequent platelet recovery by 10 days in both types of mice (Fig.4).

Although the initial platelet number was smaller in the mutant mice than in the wild-type animals, the increase in the number of. Although platelet‐activating factor (PAF) is implicated as an important mediator in the pathogenesis of hepatic ischemia‐reperfusion (IR) injury, the precise mechanism of its action has not been studied.

We examined the hypothesis that PAF may influence neutrophils by promoting the production of tumor necrosis factor α (TNF‐α) and Cited by: Factor VIIa binds to tissue factor (TF) to activate factor X, generating factor Xa. Factor Xa then binds to factor Va.

The complex of factors Xa and V converts prothrombin (Pro) to thrombin (T).Thrombin can then either bind to TM or carry out procoagulant reactions like fibrin formation or platelet : Charles T. Esmon. Like many of us in the scientific community, Cayman is monitoring and responding accordingly to the COVID pandemic.

We have enacted on-site policies to protect our employees and our local community while continuing to provide the kits, antibodies, proteins, biochemicals, and contract services you depend on to keep your research going.

Platelets are key players in the thrombotic processes. The alterations of platelet function due to the occurrence of metabolic disorders contribute to an increased trend to thrombus formation and arterial occlusion, thus playing a major role in the increased risk of atherothrombotic events in patients with cardiometabolic risk factors.

Several lines of evidence strongly correlate Author: Cristina Barale, Isabella Russo. Possibly more importantly is the fact that HRGP strongly inhibits polyphosphate induced factor XII autoactivation via increased Zn 2+ levels in response to local platelet activation, showing it to be a significant modulator of factor XII activation during sepsis and inflammation.

Because of its negative acute phase nature this will allow Cited by: 4. Macrophage Activation Syndrome MK Kumar*, MK Suresh**, D Dalus*** Abstract Macrophage Activation Syndrome is a rare and potentially fatal disease, to be considered in patients with a SIRS like clinical presentation.

Falling ESR and hyperferritinemia in the appropriate clinical setting can be the greatest by: 2. In contrast, platelet sensitivity to a PDE-resistant cAMP analogue remained normal. Genetic deletion of CD36, protected dyslipidaemic animals from PGI2 hyposensitivity and restored PKA signalling.

These data suggest that CD36 can translate atherogenic lipid stress into platelet hyperactivity through modulation of inhibitory cAMP signalling.

SUMMARY Professional phagocytes (polymorphonuclear neutrophils and monocytes/macrophages) are a main component of the immune system. These cells are involved in both host defenses and various pathological settings characterized by excessive inflammation.

Accordingly, they are key targets for immunomodulatory drugs, among which antibacterial Cited by:   1. Introduction. There is abundant evidence for a close interaction between inflammation and coagulation systems and a bidirectional cooperation between these mechanisms has been proposed.

1,2 Although the important contribution of blood cells involved in coagulation, particularly platelets and leucocytes, to atherothrombosis is beyond dispute, the Cited by: α-plasmin inhibitorCited by: Platelet-activating factor antagonism in rabbit platelets by the derivative of ochotensimine isolated from corydalis ochotensis.

Asia Pacific Journal of Pharmacology. ;7(2) Lin, C. ; Wu, Yang-Chang ; Lu, S. ; Huang, T. ; Teng, C. / Platelet-activating factor antagonism in rabbit platelets by the derivative of Author: Chien-Huang Lin, Y.

Wu, S. Lu, T. Huang, C. Teng. Mesenchymal stem cells (MSCs) have emerged as a potent therapeutic tool for the treatment of a number of pathologies, including immune pathologies. However, unwelcome effects of MSCs on blood coagulation have been reported, motivating us to explore the thrombotic properties of human MSCs from the umbilical cord.

We revealed strong procoagulant effects of MSCs on Cited by: 4. PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling.

1,2,3,4,5 Northern blot analysis. Human platelet derived growth factor-alpha (PDGFR-α) receptor has been found to be a requirement for the infection of human cells by human cytomegalovirus (HCMV), the herpesvirus that's the most.

Search all content. Search Advanced Search. Quick Search in JournalsCited by: CONCLUSIONS Platelet-derived growth factor signaling critically regulates postinfarction repair.

Both PDGFR- – and PDGFR- –mediated pathways promote collagen deposition in the infarct. Activation of PDGF-B/PDGFR- is also involved in recruitment of mural cells by neovessels, regulating maturation of the infarct by:   Tissue factor (TF) activation of the coagulation proteases enhances inflammation in animal models of arthritis and endotoxemia, but the mechanism of this effect is not yet fully understood – in particular, whether this is primarily due to fibrin formation or through activation of protease activated receptors (PARs).

We induced extravascular inflammation by injection of Cited by: Author summary Dengue is the most frequent hemorrhagic viral disease and re-emergent infection in the world. Recent decades were marked by a progressive global expansion of the infection including a higher frequency of severe dengue.

Currently there is no effective vaccinal coverage or specific therapies, while efforts aimed at vector control have failed to stop the Cited by:. Purchase Pathobiology of the Endothelial Cell - 1st Edition. Print Book & E-Book.

ISBNdiolabeledplatelet-activating factor, 1-O-Ihexadecyl-9, Hacetyl-sn-glycerophosphocholine (I3HIPAF),andthen me-tabolized it into its snfatty acyl derivative. Fractionation of radiolabel-pretreated cells over Percoll gradients revealed that virtually all of the intact PHJPAF was located in nongranule.Platelet-derived growth factor-activated receptor activity Antibodies Antibodies for proteins involved in platelet-derived growth factor-activated receptor activity pathways; according to their Panther/Gene Ontology Classification.